Single-cell Proteomic DataBase (SPDB) is a comprehensive repository for general single-cell proteomic data, encompassing both antibody-based and mass spectrometry-based single-cell proteomics, and provides dataset/protein search, visualization and download with unified formats.
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Retrived Datasets: 143
Comprehensive Immune Monitoring of Clinical Trials to Advance Human Immunotherapy

Species:Homo sapiens

Tissue:blood

Disease:leukemia

Technology Type:Antibody based

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Comprehensive Immune Monitoring of Clinical Trials to Advance Human Immunotherapy

Species:Homo sapiens

Tissue:blood

Disease:none

Technology Type:Antibody based

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High-grade serous ovarian tumor cells modulate NK cell function to create an immune-tolerant microenvironment

Species:Homo sapiens

Tissue:tumor

Disease:high-grade serous ovarian cancer

Technology Type:Antibody based

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High-grade serous ovarian tumor cells modulate NK cell function to create an immune-tolerant microenvironment

Species:Homo sapiens

Tissue:tumor

Disease:high-grade serous ovarian cancer

Technology Type:Antibody based

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Commonly Occurring Cell Subsets in High-Grade Serous Ovarian Tumors Identified by Single-Cell Mass Cytometry

Species:Homo sapiens

Tissue:tumor

Disease:high-grade serous ovarian cancer

Technology Type:Antibody based

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Distinct Immune Signatures in Peripheral Blood Predict Chemosensitivity in Intrahepatic Cholangiocarcinoma Patients

Species:Homo sapiens

Tissue:blood

Disease:intrahepatic cholangiocarcinoma

Technology Type:Antibody based

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Multidimensional analyses of proinsulin peptide-specific regulatory T cells induced by tolerogenic dendritic cells

Species:Homo sapiens

Tissue:T cells

Disease:none

Technology Type:Antibody based

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Clustergrammer, a web-based heatmap visualization and analysis tool for high-dimensional biological data

Species:Homo sapiens

Tissue:blood

Disease:none

Technology Type:Antibody based

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Trajectory and Functional Analysis of PD-1highĀ CD4+CD8+Ā T Cells in Hepatocellular Carcinoma by Single-Cell Cytometry and Transcriptome Sequencing

Species:Homo sapiens

Tissue:tumor

Disease:hepatocellular carcinoma

Technology Type:Antibody based

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Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir

Species:Homo sapiens

Tissue:blood

Disease:HIV

Technology Type:Antibody based

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Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients

Species:Homo sapiens

Tissue:blood

Disease:cytomegalovirus viremia

Technology Type:Antibody based

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Immune phenotyping of diverse syngeneic murine brain tumors identifies immunologically distinct types

Species:Homo sapiens

Tissue:tumor

Disease:glioblastoma

Technology Type:Antibody based

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Immune phenotyping of diverse syngeneic murine brain tumors identifies immunologically distinct types

Species:Mus musculus

Tissue:tumor

Disease:glioblastoma

Technology Type:Antibody based

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Single-cell phenotypic profiling to identify a set of immune cell protein biomarkers for relapsed and refractory diffuse large B cell lymphoma: A single-center study

Species:Homo sapiens

Tissue:blood

Disease:diffuse large B-cell lymphoma

Technology Type:Antibody based

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Single-cell metabolic profiling of human cytotoxic T cells

Species:Homo sapiens

Tissue:blood

Disease:none

Technology Type:Antibody based

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Single-cell metabolic profiling of human cytotoxic T cells

Species:Homo sapiens

Tissue:blood

Disease:none

Technology Type:Antibody based

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Single-cell metabolic profiling of human cytotoxic T cells

Species:Homo sapiens

Tissue:tumor

Disease:colorectal carcinoma

Technology Type:Antibody based

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Immune Profiling in Gastric Cancer Reveals the Dynamic Landscape of Immune Signature Underlying Tumor Progression

Species:Homo sapiens

Tissue:blood/tumor/non-tumor adjacent tissues

Disease:gastric cancer

Technology Type:Antibody based

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Single-cell glycomics analysis by CyTOF-Lec reveals glycan features defining cells differentially susceptible to HIV

Species:Homo sapiens

Tissue:blood/endometrium/tumor tissues

Disease:HIV

Technology Type:Antibody based

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Peripheral immunophenotyping of AITD subjects reveals alterations in immune cells in pediatric vs adult-onset AITD

Species:Homo sapiens

Tissue:blood

Disease:autoimmune thyroid disease

Technology Type:Antibody based

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CyTOF and CITE-seq T1D B cell normalized data set

Species:Homo sapiens

Tissue:B cells

Disease:type 1 diabetes

Technology Type:Antibody based

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Twin study reveals non-heritable immune perturbations in multiple sclerosis

Species:Homo sapiens

Tissue:blood

Disease:multiple sclerosis

Technology Type:Antibody based

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Twin study reveals non-heritable immune perturbations in multiple sclerosis

Species:Homo sapiens

Tissue:blood

Disease:multiple sclerosis

Technology Type:Antibody based

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Human Lymph Nodes Maintain TCF-1hiĀ Memory T Cells with High Functional Potential and Clonal Diversity throughout Life

Species:Homo sapiens

Tissue:multiple lymphoid and mucosal tissues

Disease:none

Technology Type:Antibody based

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Natural Killer Cell Receptors and Ligands Are Associated With Markers of HIV-1 Persistence in Chronically Infected ART Suppressed Patients

Species:Homo sapiens

Tissue:NK cells

Disease:HIV

Technology Type:Antibody based

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Natural Killer Cell Receptors and Ligands Are Associated With Markers of HIV-1 Persistence in Chronically Infected ART Suppressed Patients

Species:Homo sapiens

Tissue:blood

Disease:HIV

Technology Type:Antibody based

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Differential Dynamics of the Maternal Immune System in Healthy Pregnancy and Preeclampsia

Species:Homo sapiens

Tissue:blood

Disease:preeclampsia

Technology Type:Antibody based

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Genetic and Environmental Determinants of Human NK Cell Diversity Revealed by Mass Cytometry

Species:Homo sapiens

Tissue:blood

Disease:none

Technology Type:Antibody based

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Protracted yet Coordinated Differentiation of Long-Lived SARS-CoV-2-Specific CD8+Ā T Cells during Convalescence

Species:Homo sapiens

Tissue:blood

Disease:COVID-19

Technology Type:Antibody based

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Complement activation induces excessive T cell cytotoxicity in severe COVID-19

Species:Homo sapiens

Tissue:blood

Disease:COVID-19

Technology Type:Antibody based

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Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis

Species:Homo sapiens

Tissue:bone marrow

Disease:acute myeloid leukemia

Technology Type:Antibody based

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A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer

Species:Homo sapiens

Tissue:primary mammary gland tissue

Disease:breast cancer

Technology Type:Antibody based

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HIV efficiently infects T cells from the endometrium and remodels them to promote systemic viral spread

Species:Homo sapiens

Tissue:blood/endometrium

Disease:HIV

Technology Type:Antibody based

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CD4 T cell receptor hierarchies are stable and independent of HIV-mediated dysregulation of immune homeostasis

Species:Homo sapiens

Tissue:blood

Disease:HIV

Technology Type:Antibody based

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CD4 T cell receptor hierarchies are stable and independent of HIV-mediated dysregulation of immune homeostasis

Species:Homo sapiens

Tissue:blood

Disease:HIV

Technology Type:Antibody based

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Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia

Species:Mus musculus

Tissue:bone marrow

Disease:acute myeloid leukemia

Technology Type:Antibody based

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SARS-CoV-2-Specific T Cells Exhibit Phenotypic Features of Helper Function, Lack of Terminal Differentiation, and High Proliferation Potential

Species:Homo sapiens

Tissue:blood

Disease:COVID-19

Technology Type:Antibody based

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High-dimensional CyTOF analysis of dengue virusā€“infected human DCs reveals distinct viral signatures

Species:Homo sapiens

Tissue:Monocyte-derived dendritic cells (DCs)

Disease:dengue

Technology Type:Antibody based

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Hypothalamic circuitry underlying stress-induced insomnia and peripheral immunosuppression

Species:Mus musculus

Tissue:blood

Disease:insomnia

Technology Type:Antibody based

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Common and Divergent Features of T Cells from Blood, Gut, and Genital Tract of Antiretroviral Therapyā€“Treated HIV+Ā Women

Species:Homo sapiens

Tissue:blood/endometrium/endocervix/ectocervix/ileum/rectosigmoid/right colon

Disease:HIV

Technology Type:Antibody based

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mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection status

Species:Homo sapiens

Tissue:blood

Disease:COVID-19

Technology Type:Antibody based

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Decade-long leukaemia remissions with persistence of CD4+Ā CAR T cells

Species:Homo sapiens

Tissue:blood

Disease:chronic lymphocytic leukaemia

Technology Type:Antibody based

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Deep Phenotypic Analysis of Blood and Lymphoid T and NK Cells From HIV+ Controllers and ART-Suppressed Individuals

Species:Homo sapiens

Tissue:blood/lymphoid tissue

Disease:HIV

Technology Type:Antibody based

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Postnatal depletion of maternal cells biases T lymphocytes and natural killer cellsā€™ profiles toward early activation in the spleen

Species:Mus musculus

Tissue:spleen/thymus

Disease:none

Technology Type:Antibody based

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Characterization of HIV-induced remodeling reveals differences in infection susceptibility of memory CD4+Ā TĀ cell subsetsĀ inĀ vivo

Species:Homo sapiens

Tissue:blood

Disease:HIV

Technology Type:Antibody based

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Non-terminally exhausted tumor-resident memory HBV-specific TĀ cell responses correlate with relapse-free survival in hepatocellular carcinoma

Species:Homo sapiens

Tissue:blood/tumor/healthy liver margin/healthy liver/healthy fetal liver

Disease:hepatocellular carcinoma

Technology Type:Antibody based

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Deep immunophenotyping reveals endometriosis is marked by dysregulation of the mononuclear phagocytic system in endometrium and peripheral blood

Species:Homo sapiens

Tissue:blood/endometrium

Disease:endometriosis

Technology Type:Antibody based

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Deep immunophenotyping reveals endometriosis is marked by dysregulation of the mononuclear phagocytic system in endometrium and peripheral blood

Species:Homo sapiens

Tissue:blood/endometrium

Disease:endometriosis

Technology Type:Antibody based

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Implementing Mass Cytometry at the Bedside to Study the Immunological Basis of Human Diseases: Distinctive Immune Features in Patients with a History of Term or Preterm Birth

Species:Homo sapiens

Tissue:blood

Disease:preterm birth

Technology Type:Antibody based

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Immunostimulatory and anti-tumor metronomic cyclophosphamide regimens assessed in primary orthotopic and metastatic murine breast cancer

Species:Mus musculus

Tissue:EMT6-CDDP tumors

Disease:breast cancer

Technology Type:Antibody based

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The identification and functional analysis of CD8+PD-1+CD161+ T cells in hepatocellular carcinoma

Species:Homo sapiens

Tissue:blood/tumor/non-tumor adjacent tissues

Disease:hepatocellular carcinoma

Technology Type:Antibody based

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The identification and functional analysis of CD8+PD-1+CD161+ T cells in hepatocellular carcinoma

Species:Homo sapiens

Tissue:blood/tumor/non-tumor adjacent tissues

Disease:hepatocellular carcinoma

Technology Type:Antibody based

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Highly-multiplexed mass cytometry screen of human bone marrow hematopoietic stem and progenitor cells

Species:Homo sapiens

Tissue:bone marrow

Disease:none

Technology Type:Antibody based

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Highly-multiplexed mass cytometry screen of human bone marrow hematopoietic stem and progenitor cells

Species:Homo sapiens

Tissue:bone marrow

Disease:none

Technology Type:Antibody based

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Highly-multiplexed mass cytometry screen of human bone marrow hematopoietic stem and progenitor cells

Species:Homo sapiens

Tissue:bone marrow

Disease:none

Technology Type:Antibody based

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Highly-multiplexed mass cytometry screen of human bone marrow hematopoietic stem and progenitor cells

Species:Homo sapiens

Tissue:bone marrow

Disease:none

Technology Type:Antibody based

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Highly-multiplexed mass cytometry screen of human bone marrow hematopoietic stem and progenitor cells

Species:Homo sapiens

Tissue:bone marrow

Disease:none

Technology Type:Antibody based

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Highly-multiplexed mass cytometry screen of human bone marrow hematopoietic stem and progenitor cells

Species:Homo sapiens

Tissue:bone marrow

Disease:none

Technology Type:Antibody based

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Highly-multiplexed mass cytometry screen of human bone marrow hematopoietic stem and progenitor cells

Species:Homo sapiens

Tissue:bone marrow

Disease:none

Technology Type:Antibody based

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Highly-multiplexed mass cytometry screen of human bone marrow hematopoietic stem and progenitor cells

Species:Homo sapiens

Tissue:bone marrow

Disease:none

Technology Type:Antibody based

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Highly-multiplexed mass cytometry screen of human bone marrow hematopoietic stem and progenitor cells

Species:Homo sapiens

Tissue:bone marrow

Disease:none

Technology Type:Antibody based

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Highly-multiplexed mass cytometry screen of human bone marrow hematopoietic stem and progenitor cells

Species:Homo sapiens

Tissue:bone marrow

Disease:none

Technology Type:Antibody based

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Highly-multiplexed mass cytometry screen of human bone marrow hematopoietic stem and progenitor cells

Species:Homo sapiens

Tissue:bone marrow

Disease:none

Technology Type:Antibody based

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Highly-multiplexed mass cytometry screen of human bone marrow hematopoietic stem and progenitor cells

Species:Homo sapiens

Tissue:bone marrow

Disease:none

Technology Type:Antibody based

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Highly-multiplexed mass cytometry screen of human bone marrow hematopoietic stem and progenitor cells

Species:Homo sapiens

Tissue:bone marrow

Disease:none

Technology Type:Antibody based

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Highly-multiplexed mass cytometry screen of human bone marrow hematopoietic stem and progenitor cells

Species:Homo sapiens

Tissue:bone marrow

Disease:none

Technology Type:Antibody based

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Highly-multiplexed mass cytometry screen of human bone marrow hematopoietic stem and progenitor cells

Species:Homo sapiens

Tissue:bone marrow

Disease:none

Technology Type:Antibody based

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Comparative immune profiling of acute respiratory distress syndrome patients with or without SARS-CoV-2 infection

Species:Homo sapiens

Tissue:myeloid tissue

Disease:acute respiratory distress syndrome

Technology Type:Antibody based

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Comparative immune profiling of acute respiratory distress syndrome patients with or without SARS-CoV-2 infection

Species:Homo sapiens

Tissue:lymphoid tissue

Disease:acute respiratory distress syndrome

Technology Type:Antibody based

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A distinct innate immune signature marks progression from mild to severe COVID-19

Species:Homo sapiens

Tissue:blood

Disease:COVID-19

Technology Type:Antibody based

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A distinct innate immune signature marks progression from mild to severe COVID-19

Species:Homo sapiens

Tissue:blood

Disease:COVID-19

Technology Type:Antibody based

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A distinct innate immune signature marks progression from mild to severe COVID-19

Species:Homo sapiens

Tissue:blood

Disease:COVID-19

Technology Type:Antibody based

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Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19

Species:Homo sapiens

Tissue:blood

Disease:COVID-19

Technology Type:Antibody based

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Alignment of single-cell trajectories by tuMap enables high-resolution quantitative comparison of cancer samples

Species:Homo sapiens

Tissue:bone marrow

Disease:acute lymphoblastic and myeloid leukemia

Technology Type:Antibody based

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Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients

Species:Homo sapiens

Tissue:blood

Disease:COVID-19

Technology Type:Antibody based

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Single-Cell Mapping of Human Brain Cancer Reveals Tumor-Specific Instruction of Tissue-Invading Leukocytes

Species:Homo sapiens

Tissue:brain

Disease:brain tumors

Technology Type:Antibody based

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Single-Cell Mapping of Human Brain Cancer Reveals Tumor-Specific Instruction of Tissue-Invading Leukocytes

Species:Homo sapiens

Tissue:brain

Disease:brain tumors

Technology Type:Antibody based

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A Single-Cell Atlas of Tumor-Infiltrating Immune Cells in Pancreatic Ductal Adenocarcinoma

Species:Homo sapiens

Tissue:blood/tumor/non-tumor adjacent tissues

Disease:pancreatic ductal adenocarcinoma; chronic pancreatitis

Technology Type:Antibody based

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Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response

Species:Mus musculus

Tissue:tumor

Disease:breast cancer

Technology Type:Antibody based

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Inter and intra-tumor heterogeneity of paediatric type diffuse high-grade gliomas revealed by single-cell mass cytometry

Species:Homo sapiens

Tissue:tumor

Disease:paediatric-type diffuse high-grade gliomas

Technology Type:Antibody based

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Comprehensive innate immune profiling of chikungunya virus infection in pediatric cases

Species:Homo sapiens

Tissue:blood

Disease:chikungunya virus

Technology Type:Antibody based

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In depth comparative phenotyping of blood innate myeloid leukocytes from healthy humans and macaques using mass cytometry

Species:Homo sapiens

Tissue:blood

Disease:none

Technology Type:Antibody based

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In depth comparative phenotyping of blood innate myeloid leukocytes from healthy humans and macaques using mass cytometry

Species:Macaca mulatta

Tissue:blood

Disease:none

Technology Type:Antibody based

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Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19

Species:Homo sapiens

Tissue:blood

Disease:multisystem inflammatory syndrome; COVID-19

Technology Type:Antibody based

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Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

Species:Homo sapiens

Tissue:glioblastoma tissue

Disease:glioblastoma

Technology Type:Antibody based

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Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

Species:Mus musculus

Tissue:glioblastoma tissue

Disease:glioblastoma

Technology Type:Antibody based

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Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

Species:Homo sapiens

Tissue:liver

Disease:obese

Technology Type:Antibody based

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Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

Species:Mus musculus

Tissue:liver

Disease:none

Technology Type:Antibody based

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Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

Species:Mus musculus

Tissue:liver

Disease:nonalcoholic fatty liver disease

Technology Type:Antibody based

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Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

Species:Sus scrofa

Tissue:liver

Disease:none

Technology Type:Antibody based

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Joint probabilistic modeling of single-cell multi-omic data with totalVI

Species:Mus musculus

Tissue:spleen/lymph nodes

Disease:none

Technology Type:Antibody based

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Joint probabilistic modeling of single-cell multi-omic data with totalVI

Species:Mus musculus

Tissue:spleen/lymph nodes

Disease:none

Technology Type:Antibody based

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A conserved dendritic-cell regulatory program limits antitumour immunity

Species:Homo sapiens

Tissue:lung

Disease:non-small-cell lung cancer

Technology Type:Antibody based

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A conserved dendritic-cell regulatory program limits antitumour immunity

Species:Homo sapiens

Tissue:lung

Disease:non-small-cell lung cancer

Technology Type:Antibody based

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A conserved dendritic-cell regulatory program limits antitumour immunity

Species:Homo sapiens

Tissue:lung

Disease:non-small-cell lung cancer

Technology Type:Antibody based

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Single-cell immune landscape of human atherosclerotic plaques

Species:Homo sapiens

Tissue:blood/carotid artery plaques

Disease:atherosclerosis

Technology Type:Antibody based

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Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19

Species:Homo sapiens

Tissue:blood

Disease:COVID-19

Technology Type:Antibody based

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Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19

Species:Homo sapiens

Tissue:blood

Disease:COVID-19

Technology Type:Antibody based

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Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia

Species:Homo sapiens

Tissue:bone marrow

Disease:acute myeloid leukemia

Technology Type:Antibody based

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Single-cell antigen-specific landscape of CAR T infusion product identifies determinants of CD19-positive relapse in patients with ALL

Species:Homo sapiens

Tissue:blood

Disease:acute lymphoblastic leukemia

Technology Type:Antibody based

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Single-cell antigen-specific landscape of CAR T infusion product identifies determinants of CD19-positive relapse in patients with ALL

Species:Homo sapiens

Tissue:blood

Disease:acute lymphoblastic leukemia

Technology Type:Antibody based

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Single-cell antigen-specific landscape of CAR T infusion product identifies determinants of CD19-positive relapse in patients with ALL

Species:Homo sapiens

Tissue:blood

Disease:acute lymphoblastic leukemia

Technology Type:Antibody based

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Single-cell antigen-specific landscape of CAR T infusion product identifies determinants of CD19-positive relapse in patients with ALL

Species:Homo sapiens

Tissue:blood

Disease:acute lymphoblastic leukemia

Technology Type:Antibody based

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Broad immune activation underlies shared set point signatures for vaccine responsiveness in healthy individuals and disease activity in patients with lupus

Species:Homo sapiens

Tissue:blood

Disease:none

Technology Type:Antibody based

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A RORĪ³t+ cell instructs gut microbiota-specific Treg cell differentiation

Species:Mus musculus

Tissue:mesenteric lymph nodes

Disease:none

Technology Type:Antibody based

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T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers

Species:Macaca mulatta

Tissue:vaginal tissue

Disease:SHIV infection

Technology Type:Antibody based

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Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion

Species:Homo sapiens

Tissue:tumor

Disease:melanoma

Technology Type:Antibody based

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Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia

Species:Homo sapiens

Tissue:bone marrow

Disease:B cell acute lymphoblastic leukemia

Technology Type:Antibody based

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Clonal lineage tracing reveals shared origin of conventional and plasmacytoid dendritic cells

Species:Mus musculus

Tissue:bone marrow

Disease:none

Technology Type:Antibody based

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Clonal lineage tracing reveals shared origin of conventional and plasmacytoid dendritic cells

Species:Mus musculus

Tissue:bone marrow

Disease:none

Technology Type:Antibody based

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Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states

Species:Homo sapiens

Tissue:bone marrow

Disease:acute myeloid leukemia

Technology Type:Antibody based

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Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states

Species:Homo sapiens

Tissue:blood/bone marrow

Disease:none

Technology Type:Antibody based

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Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states

Species:Homo sapiens

Tissue:bone marrow

Disease:none

Technology Type:Antibody based

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Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states

Species:Homo sapiens

Tissue:bone marrow

Disease:none

Technology Type:Antibody based

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Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease

Species:Homo sapiens

Tissue:blood

Disease:Peruvian tuberculosis disease

Technology Type:Antibody based

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Single-cell transcriptomics and surface epitope detection in human brain epileptic lesions identifies pro-inflammatory signaling

Species:Homo sapiens

Tissue:brain

Disease:epilepsy

Technology Type:Antibody based

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An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia

Species:Homo sapiens

Tissue:bone marrow

Disease:acute myeloid leukemia

Technology Type:Antibody based

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Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19

Species:Homo sapiens

Tissue:blood

Disease:COVID-19

Technology Type:Antibody based

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Multi-modal profiling of human fetal liver hematopoietic stem cells reveals the molecular signature of engraftment

Species:Homo sapiens

Tissue:fetal liver

Disease:none

Technology Type:Antibody based

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Murine fetal bone marrow does not support functional hematopoietic stem and progenitor cells until birth

Species:Mus musculus

Tissue:bone marrow

Disease:none

Technology Type:Antibody based

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Multiomics reveals persistence of obesity-associated immune cell phenotypes in adipose tissue during weight loss and weight regain in mice

Species:Mus musculus

Tissue:epididymal adipose tissue

Disease:none

Technology Type:Antibody based

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Tracing tumorigenesis in a solid tumor model at single-cell resolution

Species:Mus musculus

Tissue:submandibular gland

Disease:salivary gland squamous cell carcinoma

Technology Type:Antibody based

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Multi-modal Single-Cell Analysis Reveals Brain Immune Landscape Plasticity during Aging and Gut Microbiota Dysbiosis

Species:Mus musculus

Tissue:brain

Disease:none

Technology Type:Antibody based

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Identifying CNS-colonizing T cells as potential therapeutic targets to prevent progression of multiple sclerosis

Species:Homo sapiens

Tissue:blood

Disease:multiple sclerosis

Technology Type:Antibody based

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Influenza vaccination reveals sex dimorphic imprints of prior mild COVID-19

Species:Homo sapiens

Tissue:blood

Disease:COVID-19

Technology Type:Antibody based

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Monocyte-derived transcriptome signature indicates antibody-dependent cellular phagocytosis as a potential mechanism of vaccine-induced protection against HIV-1

Species:Homo sapiens

Tissue:blood

Disease:HIV

Technology Type:Antibody based

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Integrated analysis of multimodal single-cell data

Species:Homo sapiens

Tissue:blood

Disease:none

Technology Type:Antibody based

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Integrated analysis of multimodal single-cell data

Species:Homo sapiens

Tissue:blood

Disease:none

Technology Type:Antibody based

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Targeting CXCL16 and STAT1 augments immune checkpoint blockade therapy in triple-negative breast cancer

Species:Mus musculus

Tissue:tumor

Disease:breast cancer

Technology Type:Antibody based

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JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm

Species:Mus musculus

Tissue:aorta

Disease:aortic aneurysm

Technology Type:Antibody based

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Absence of Batf3 reveals a new dimension of cell state heterogeneity within conventional dendritic cells

Species:Mus musculus

Tissue:spleen

Disease:none

Technology Type:Antibody based

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Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia

Species:Homo sapiens

Tissue:bone marrow

Disease:acute myeloid leukemia

Technology Type:Antibody based

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Multimodal single-cell analysis of cutaneous T-cell lymphoma reveals distinct subclonal tissue-dependent signatures

Species:Homo sapiens

Tissue:blood/skin

Disease:cutaneous T cell lymphoma

Technology Type:Antibody based

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High-throughput and high-efficiency sample preparation for single-cell proteomics using a nested nanowell chip

Species:Mus musculus

Tissue:cell lines

Disease:none

Technology Type:Mass Spectrometry based

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High-Throughput Single Cell Proteomics Enabled by Multiplex Isobaric Labelling in a Nanodroplet Sample Preparation Platform

Species:Mus musculus

Tissue:cell lines

Disease:none

Technology Type:Mass Spectrometry based

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Increasing the throughput of sensitive proteomics by plexDIA

Species:Homo sapiens

Tissue:cell lines

Disease:none

Technology Type:Mass Spectrometry based

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Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomics

Species:Homo sapiens

Tissue:cell lines

Disease:none

Technology Type:Mass Spectrometry based

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Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomics

Species:Mus musculus

Tissue:bone marrow

Disease:none

Technology Type:Mass Spectrometry based

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Prioritized single-cell proteomics reveals molecular and functional polarization across primary macrophages

Species:Homo sapiens

Tissue:cell lines

Disease:none

Technology Type:Mass Spectrometry based

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Exploring functional protein covariation across single cells using nPOP

Species:Homo sapiens

Tissue:cell lines

Disease:none

Technology Type:Mass Spectrometry based

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Exploring functional protein covariation across single cells using nPOP

Species:Homo sapiens

Tissue:cell lines

Disease:none

Technology Type:Mass Spectrometry based

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Single-cell proteomic and transcriptomic analysis of macrophage heterogeneity using SCoPE2

Species:Homo sapiens

Tissue:cell lines

Disease:none

Technology Type:Mass Spectrometry based

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Ultra-high sensitivity mass spectrometry quantifies single-cell proteome changes upon perturbation

Species:Homo sapiens

Tissue:cell lines

Disease:none

Technology Type:Mass Spectrometry based

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